Ho potlakisa tlhahlobo e tšepahalang ea mafu

Ho fumanoa ha mafu a tšoaetsanoang ka nako e khutšoanyane ho beha baahi ba bangata kotsing lefatšeng la rona le kopaneng, haholo-holo ka likokoana-hloko tsa liphoofolo tse tšoaetsanoang ke liphoofolo tse phelang le batho. Ho hakanngoa hore 75% ea likokoana-hloko tse 30 tse sa tsoa fumanoa tse tlalehiloeng lilemong tse 30 tse fetileng ka 2008 li tsoa liphoofolong, ho latela tlaleho ea WHO e lokollotsoeng ka 2021.

"Sehlopha sa rona se inehetse ho hlola liphephetso tsa moralo oa tlhahlobo ea mafu ho sebeletsa tlhoko ea tlhahlobo ea mafu bakeng sa lebelo la POCT le phihlello ho IVD ka bobeli (ka hare ho vitro) le e seng ea IVD,” ho bolela Lianyi Xie, ea thehileng Hangzhou Bigfish Bio-tech Co., Ltd, ka 2017. “Liteko tsa rona tsa tlhokomelo (POCT) li etselitsoe ho sebetsa ka potlako maemong a fokolang a mehloli, ha ka nako e ts'oanang li thusa mefuta e fapaneng ea mafu.”

Li-POCT tsa Bigfish li etselitsoe ho sireletsa polokeho ea lijo, hammoho le bophelo bo botle ba liphoofolo tse ruuoang le liphoofolo tse tsamaeang le tsona, haholo-holo ha ho nahanoa ka palo e ntseng e eketseha ea beng ba liphoofolo tse ruuoang lapeng Chaena.

Xie o hlalositse hore tumello ea moralo oa POCT e potlakileng e tlameha ho tsamaea ka tekano e ntle pakeng tsa boqapi le ho tsepamisa maikutlo theknolojing ea amplification ea setso le e tšepahalang, e thehiloeng ho karabelo ea ketane ea polymerase (PCR), ho lemoha bongata bo fokolang ba li-nucleic acid ho tsoa mecheng e rarahaneng.

Nahana ka ho qhoma ha feberu ea likolobe ea Afrika (ASF) Chaena, e leng lehae la 'maraka o moholo ka ho fetisisa oa tlhahiso le tšebeliso ea nama ea kolobe lefatšeng. Ka 2019, ASF e bakile lefu la likolobe tse fetang limilione tse 43, 'me e bakile tahlehelo ea liranta tse limilione tse likete tse 111. Ho potlakisa meralo ea POCT ho itšetlehile ka tšebelisano-'moho e haufi-ufi le mekhatlo ea thuto le ea mmuso, hammoho le maikutlo a tsoang ho basebelisi, joalo ka barui ba likolobe ba ka sehloohong ba Chaena.

“Ho nepahala le kutlwisiso e lekanang le dibaka tsa laboratori, esita le mapolasing a manyane a hole, ke tsa bohlokwa bakeng sa dikiti tsa rona, tse entsweng hore di be theko e tlase mme di be bonolo ho sebediswa ho modisa ofe kapa ofe wa dikolobe,” ho hlalosa Xie.

Mosebetsi oa Bigfish oa ho thibela le ho felisa mafu naheng ka bophara o boetse o atolohela ho brucellosis, e leng lefu le atileng haholo la zoonotic lefatšeng ka bophara, hammoho le mafu a liphoofolo tse tsamaeang le tsona.

Bigfish e nolofalitse POCT ka potlako litsing tsa bongaka ba liphoofolo tse ka bang 4,000 ho pholletsa le Chaena. Shuilin Zhu, modulasetulo oa Mokhatlo oa Tšireletso ea Liphoofolo tse Nyenyane oa Zhejiang, o ekelitse ka hore mahlale a k'hamphani bakeng sa liphoofolo

Tlhokomelo ea liphoofolo tse ruuoang lapeng ha ea eketsa feela katleho ea thibelo le taolo, empa hape e ntlafatsa boiketlo ba liphoofolo haholo.

Ho nolofalletsa moralo o monyane ntle le litšenyehelo tse ngata bakeng sa basebelisi ke ntho e 'ngoe ea bohlokoa moralong le tlhahisong ea liteko tsa bona tsa lefutso. Teko ea bona ea tlhahlobo ea limolek'hule GeNext ha e kholo ho feta botlolo ea metsi, 'me e boima ba lik'hilograma tse 2. E na le li-chip tsa mesofluidic le microfluidic tse iketsang mehato e boima ho tloha ho ntšoeng ha nucleic acid, ho atolosoa ha liphatsa tsa lefutso ho isa ho ho kenya le ho sekaseka data ka nako ea sebele.

E koetsoe ka botlalo ho qoba tšilafalo e ka bang teng ea aerosol, GeNext 2.0 e hlahisoang ka bongata e ka nolofalletsa keketseho ea tlhahiso ea sampole ho tloha ho 1 ho isa ho 16 ka potoloho, tatellano e reriloeng e atolositsoe ho tloha ho 5 ho isa ho 25 ka ho matha, ntle le nako kapa litšenyehelo tse eketsehileng.

“Meralo ea rona ea GeNext 3.0 e tla fokotsa nako haholoanyane, e ntlafatse ka li-chip tse thehiloeng ho silicon, 'me e kenyelelitse mahlale a tatellano a kang tatellano ea nanopore bakeng sa moelelo o pharaletseng oa bongaka tlhahlobong ea pelehi le tlhahlobo ea kankere ea pele ho nako,” ho bolela Xie. “Meralo ea rona ea POCT e ka sebelisoa ke mang kapa mang ka letsatsi le leng, kae kapa kae ntle le ho nahana ka litšenyehelo.”