Phatlalatso ea Phase Kiii e sephara se sephakeng se secha sa Chaena sethethefatsi sa Nejm Shows

Lihora tsa la 29 Tšitoe, Nejm o ile a phatlalatsa inthaneteng ea Clilical plilical iii ea Kolo ea New Chinese Coronavirus VV116. Liphetho li bontšitse hore VV116 ha ho ne ho le mpe ho feta paxlovir (nematovir / ritonavir) mabapi le ho fola ha nako ea ho fola 'me ho bile le liketsahalo tse fokolang tse mpe.

Mohloli oa setšoantšo: nejm

Ho hlaphoheloa ha Mediation matsatsi a 4, maemo a bohloko a 67.4%

VV116 ke sethethefatsi sa coro-New coronavide (sar-cov-cov-cov-2) Sethethefatsi

Ka 2021, teko ea tlhaho ea VV116 e phethetsoe Uzbekistan. Liphetho tsa Phuputso li bontšitse hore sehlopha sa VVORCHA se ka ntlafala ho feta matšoao a kliniki ebile ho fokola kotsi ea ho tsoela pele ka tsela ea ho tsoela pele. Ho ipapisitsoe le litholoana tse ntle tsa teko ena, VV116 e amohetsoe Uzbekistan bakeng sa kalafo ea bakuli ba nang le molomo o mongata oa ho bapatsa naheng ea pele [1].

Seebili sa Clinical Clinical [2] (NCT05341609 Ho lekola katleho le polokeho ea VV116 ho fapana le ho tšoaroang bakuli ba tsoang pele ho bakuli ba 19. Morero e ne e le ho lekola katleho le polokeho ea VV116 ho fapana le ho tšoasa pele bakuli ba nang le bonolo ba 19.

Mohloli oa Litšoantšo: Book 2

Bakuli ba bangata ba foufetseng, ba ile ba tepella ka tsela e sa lebelloang, bakuli ba bangata ba kotsing e kholo ea ho tsoela pele pakeng tsa liphallelo tsa Shanghai, China. Qetellong, karolo ea 771 e amohetse vv116 (384, 600 mg lihora tse 12 ka matsatsi a 2- 38 mg ka matsatsi a 5) e le meriana ea molomo.

Liphetho tsa thuto ena ea bongaka li bontšitse hore kalafo ea pele e na le VV11

Ho boloka nako ea ho fola

Boemo ba mathomo le ba maemo a bobeli (tlhahlobo e felletseng ea baahi)

Mohloli oa Litšoantšo: Book 2

Mabapi le polokeho, barupeluoa ba amohela VV116 ba boletse liketsahalo tse fokolang (77.3%) Ho latela VV11 (2.6%).

Liketsahalo tse mpe (batho ba bolokehileng)

Mohloli oa Litšoantšo: Book 2

Likarolo le lipotso

Ka la 23 Mots'eanong 2022, Juniper o ile a senola hore thuto ea bongaka ea VV116 e khahlanong le pheko ea pele ho covidrate e thusang.

Mohloli oa setšoantšo: Book 1

Ka nako ea ha lintlha tsa nyeoe li ntse li fokola, khang e likamaneng tsa pele li ile tsa eketseha, e ne e le ho se sebetse hantle, ho tla ba thata ho laola lithethefatsi ka botlalo; Taba ea bobeli, ho ne ho e-na le lipotso mabapi le lipheo tsa nako ea bongaka.

Matšoao a tšoantšetso a Juniper ke a (i) matšoao a macha a moqhaka, (ii) e le 'ngoe kapa e bonolo kapa e leka-lekaneng kapa e leka-lekaneng. Leha ho le joalo, pheletso feela ea mantlha ea bo-claniki ke 'nako ea ho fola kalliniki ea bongaka'.

Pele ho tsebiso, ka la 14 Mots'eanong, Juniper o ne a ile a ntlafatsa pheletso ea bongaka ka ho tlosa e 'ngoe ea likhopolo tsa mantlha, "tekanyo ea liphetoho tsa ho kula kapa lefu" [3].

Mohloli oa setšoantšo: Book 1

Lintlha tsena tse peli tsa bohlokoa tsa ho batla le tsona li ne li arajoa ka ho khetheha thutong e phatlalalitsoeng.

Ka lebaka la ho phatloha ka tšohanyetso ha omicror, tlhahiso ea matlapa a lipparbo o ne a sa phethe nako ea ho qala nyeoe ka hona bafuputsi ba ile ba sitoa ho etsa nyeoe e foufetseng le e rock. Ha e le karolo e le 'ngoe e tenang ea nyeoe ea bongaka, Juniper o ile a re ho buisana ka mokhoa o hlakileng oa ho ithuta ka mokhoa o tšoanang ho fihlela database ea ho qetela e tla nona qetellong ea thuto.

Ho fihlela nako ea tlhahlobo ea ho qetela, ha ho le ea mong oa sehlopha nyeoeng e nang le lefu kapa tsoelo-pele e ka thibelang ho tsoela pele ka ho hlaka kapa e le lefu. Lintlha tse bontšitsoeng hore nako e lekantsoeng ea Media ho tsoa ho Consemente ea sepheo se kopantsoeng le li-3,06; 95% ci, 0,91 ho 1.22) [2]. Ha ho thata ho hlalosa hore na ke hobane'ng ha pheletso e ka sehloohong ea 'tekanyo ea phetoho e mpe kapa lefu', e neng e letiloe pele ho fela.

Ka la 18 Mots'eanong 2022, koranta ea ho hlaha likokoana-hloko le tšoaetso e phatlalalitsoeng ka lebaka la teko ea VVERS [leqepheng la 4]

Lintlha tse tsoang phuputsong li bontšitse hore bakuli ba nang le tšoaetso ea omicron ea neng a sebelisa vv1r ba neng ba e-na le chelete ea nyutlelie ea nyutlelie e neng e le teng. Tsamaiso ea VV116 ho bakuli ba nang le leqeba la thuto ena (matsatsi a 2-10 matsatsi a tlhahlobo ea mantlha ea nyutledic) e fokotseng khafetsa bakuli bohle. Mabapi le polokeho ea lithethefatsi, ha ho litlamorao tse mpe tse mpe tse ileng tsa bonoa sehlopha sa kalafo ea VV116.

Mohloli oa Litšoantšo: Book 4

Ho na le liteko tse tharo tse qalang tsa bongaka tse qalang ho VV116, tse peli tsa prose III li ithuta ka bonolo ho Covid-19 (NCS05242048, nc055826 Teko e 'ngoe ea ho leka-lekaneng ho ho leka-lekaneng - ea 19 ke' mala oa machaba oa "III ea nang le bofokoli tse peli tsa Motheo oa Plase Ho latela tsebiso ea Jiniper, mokuli oa pele o ile a ingolisa 'me a felisoa ka la 20 Hlakubele.

Mohloli oa setšoantšo: Clinicaltricals.gov

Litšupiso:

[1] Junshi biotech

[2] https://ww.nejm.org/Dooi/full/10.105641609 Junming Xu, Hao Yin, Zhiren Fu, Li Li, Li Met Boikah, L Rui Hua . Likokoana-hloko le tšoaetso 11: 1, leqepheng la 2636-2644.