Batho ba Leshome ba Phahameng ka ho Fetisisa ba Tlhaho:

Yunlong Cao ea Univesithi ea Peking e reheletsoe lipatlisiso tse ncha tsa coronavirus

Ka la 15 Tšitoe 2022, Tlhaho e phatlalalitse 10 ea eona ea Tlhaho, lethathamo la batho ba leshome bao e bileng karolo ea liketsahalo tse kholo tsa selemo tsa saense, le bao lipale tsa bona li fanang ka pono e ikhethang ka tse ling tsa liketsahalo tsa bohlokoa tsa saense tsa selemo sena se sa tloaelehang.

Selemong sa maqakabetsi le litšibollo tse thabisang, Nature e ile ea khetha batho ba leshome ho litsebi tsa linaleli ba re thusitseng ho utloisisa boteng ba bokahohle bo hōle ka ho fetisisa, ho bafuputsi ba thusitseng seoa sa New Crown le monkeypox, ho lingaka tse buoang tse tlōtseng meeli ea ho fetisetsa setho sa ’mele. , ho bolela Rich Monastersky, mohlophisi-ka sehloohong oa Nature Features.

Yunlong Cao o tsoa Biomedical Frontier Innovation Center (BIOPIC) Univesithing ea Peking.Dr. Cao o alohile Univesithing ea Zhejiang ka lengolo la Bachelor ho Fisiks 'me a fumana PhD ea hae Lefapheng la Khemistri le Lik'hemik'hale tsa Lik'hemik'hale Univesithing ea Harvard tlas'a Xiaoliang Xie,' me hona joale ke Motlatsi oa Lipatlisiso Setsing sa Boqapi sa Biomedical Frontier Innovation Univesithing ea Peking.Yunlong Cao esale a tsepamisitse maikutlo ho nts'etsopele ea mahlale a tatellano ea sele e le 'ngoe, mme lipatlisiso tsa hae li thusitse ho lekola phetoho ea li-coronavirus tse ncha le ho bolela esale pele liphetoho tse lebisang ho thehoeng ha mefuta e mecha ea phetoho.

Ka la 18 Motšeanong 2020, Xiaoliang Xie/Yunlong Cao et al.e phatlalalitse pampiri koranteng ea Cell e nang le sehlooho se reng: "Li-antibodies tse matla khahlanong le SARS-CoV-2 tse khetholloang ka tatellano e phahameng ea sele e le 'ngoe ea lisele tsa B tsa bakuli"

Boithuto bona bo tlaleha liphetho tsa "coronavirus" e ncha (SARS-CoV-2) skrineng sa "antigen" se sa sebetseng hantle, se sebelisitseng sethala sa tatellano ea sele e le 'ngoe ea RNA le VDJ ho tsebahatsa li-antibodies tse 14 tsa monoclonal tse tsoang ho li-antigen tse fetang 8500 tsa IgG1. Bakuli ba 60 ba folile ba COVID-19.

Phuputso ena e bonts'a lekhetlo la pele hore tatellano e phahameng ea sele e le 'ngoe e ka sebelisoa ka kotloloho bakeng sa ho sibolla lithethefatsi mme e na le molemo oa ho ba ts'ebetso e potlakileng le e sebetsang, e ts'episang ho fetola tsela eo batho ba hlahlobang ka eona bakeng sa ho fokotsa masole a 'mele ho livaerase tse tšoaetsanoang.

Ka la 17 Phuptjane 2022, Xiaoliang Xie/Yunlong Cao et al.e hatisitse pampiri e nang le sehlooho se reng: BA.2.12.1, BA.4 le BA.5 li-antibodies tse hlahisitsoeng ke ts'oaetso ea Omicron koranteng ea Nature.

Phuputso ena e fumane hore li-subtypes tse ncha tsa Omicron mutant strains BA.2.12.1, BA.4 le BA.5 li bontšitse ho eketseha ha tšireletso ea 'mele ea ho itšireletsa mafung le ho fokotseha ho hoholo ha plasma ho phonyoha ho bakuli ba nang le tšoaetso ea Omicron BA.1.

Liphuputso tsena li fana ka maikutlo a hore ente ea Omicron e thehiloeng ho BA.1 e ka 'na ea se ke ea hlola e sebetsa e le se matlafatsang boemong ba hona joale ba ho thibela liente le hore li-antibodies tse hlahisoang li ke ke tsa fana ka tšireletso e pharaletseng khahlanong le mofuta o mocha oa phetoho.Ho feta moo, ts'ireletso ea mehlape ka ts'oaetso ea Omicron e thata haholo ho e fihlela ka lebaka la "immunogenic" ea li-coronavirus tse ncha le phetoho e potlakileng ea libaka tsa phetoho ea 'mele oa ho itšireletsa mafung.

Ka la 30 Mphalane 2022, sehlopha sa Xiaoliang Xie/Yunlong Cao se phatlalalitse pampiri ea lipatlisiso e nang le sehlooho se reng: Imprinted SARS-CoV-2 humoral immune immune e susumetsa phetoho ea Omicron RBD ho bioRxiv ea pele.

Phuputso ena e fana ka maikutlo a hore molemo oa XBB ho feta BQ.1 e ka 'na ea e-ba karolo ea liphetoho tse ka ntle ho sebaka sa ho amohela li-receptor (RBD) sa spinosin, hore XBB e boetse e na le liphetoho likarolong tsa genome encoding N-terminal structural domain (NTD). ) ea spinosin, le hore XBB e khona ho baleha li-antibodies tse fokolang khahlanong le NTD, tse ka li lumellang ho tšoaetsa batho ba itšireletsang ho BQ.1 le li-subtypes tse amanang.Leha ho le joalo, ke habohlokoa ho hlokomela hore liphetoho tsa phetoho sebakeng sa NTD li etsahala BQ.1 ka lebelo le potlakileng haholo.Liphetoho tsena li ntlafatsa haholo bokhoni ba mefuta ena ea ho baleha li-antibodies tse hlahisoang ke ente le mafu a fetileng.

Dr. Yunlong Cao o boletse hore ho ka 'na ha e-ba le tšireletso e itseng khahlanong le XBB haeba e tšoaelitsoe ke BQ.1, empa lipatlisiso tse ling li hlokahala ho fana ka bopaki ba sena.

Ntle le Yunlong Cao, batho ba bang ba babeli ba entse lethathamo la tlatsetso ea bona e ikhethang litabeng tsa bophelo bo botle ba sechaba, Lisa McCorkell le Dimie Ogoina.

Lisa McCorkell ke mofuputsi ea nang le Long COVID mme joalo ka setho sa mothehi oa Patient-Led Research Collaborative, o thusitse ho phahamisa tlhokomeliso le lichelete bakeng sa lipatlisiso mabapi le lefu lena.

Dimie Ogoina ke ngaka ea mafu a tšoaetsanoang Univesithing ea Niger Delta e Nigeria 'me mosebetsi oa hae oa seoa sa monkeypox Nigeria o fane ka boitsebiso ba bohlokoa ntoeng khahlanong le seoa sa monkeypox.

Ka la 10 Pherekhong 2022, Univesithi ea Maryland School of Medicine e phatlalalitse ts'ebetso ea pele ea lefats'e e atlehileng ea ho kenya pelo ea kolobe ho motho ea phelang, ha mokuli oa pelo ea lilemo li 57 David Bennett a fumana phetisetso ea pelo ea kolobe e fetotsoeng ho pholosa bophelo ba hae. .

Le hoja pelo ena ea kolobe e ekelitse bophelo ba David Bennett ka likhoeli tse peli feela, e bile katleho e kholo le katleho ea histori lefapheng la xenotransplantation.Muhammad Mohiuddin, ngaka e buoang e neng e etelletse pele sehlopha se phethileng phetisetso ena ea pelo ea kolobe e fetotsoeng ka liphatsa tsa lefutso, ha ho pelaelo hore o ile a rehoa lethathamong la Batho ba 10 ba Phahameng ka ho Fetisisa ba Selemo.

Ba bang ba ’maloa ba ile ba khethoa bakeng sa ho ntšetsa pele likatleho tse makatsang tsa saense le tsoelopele ea bohlokoa ea maano, ho kenyeletsoa setsebi sa linaleli Jane Rigby oa Goddard Space Center ea NASA, ea ileng a phetha karolo ea bohlokoa morerong oa Webb Space Telescope oa ho kenya sebonela-hōle sepakapakeng le ho sebetsa ka nepo, ho nka bokhoni ba batho ba ho hlahloba. bokahohle ho ea boemong bo bocha le bo phahameng.alondra Nelson, joalo ka Motsamaisi oa Tšebetso ea Leano la Saense le Theknoloji ea US Ofising ea Saense le Theknoloji, o thusitse tsamaiso ea Mopresidente Biden ho nts'etsapele lintlha tsa bohlokoa tsa lenaneo la eona la mahlale, ho kenyeletsoa leano la bots'epehi ba mahlale le litataiso tse ncha mabapi le mahlale a bulehileng.Diana Greene Foster, mofuputsi oa ho ntša mpa le setsebi sa palo ea batho Univesithing ea California, San Francisco, o fane ka lintlha tsa bohlokoa mabapi le phello e lebelletsoeng ea qeto ea Lekhotla le ka Holimo-limo la United States ea ho phethola tšireletso ea molao bakeng sa litokelo tsa ho ntša mpa.

Ho boetse ho na le mabitso lenaneng la ba leshome ba holimo selemong sena a amanang le nts'etsopele ea phetoho ea maemo a leholimo le mathata a mang a lefats'e.Ke: António Guterres, Mongoli-Kakaretso oa Machaba a Kopaneng, Saleemul Huq, Mookameli oa Setsi sa Machaba sa Phetoho ea Tlelaemete le Ntšetso-pele ea Dhaka, Bangladesh, le Svitlana Krakovska, Hlooho ea moifo oa Seukraine ho Panel ea Machaba a Kopaneng mabapi le Phetoho ea Tlelaemete ( IPCC).